The prevalence of lipid metabolism related diseases has become a major public health is-sue in China.Meanwhile,iodine plays an important role in the regulation of metabolism.There have been many reports on the effects and regulatory mechanisms of iodine nutritional states on lipid metabolism,inclu-ding the thyroid-dependent direct pathway and various indirect pathways.However,research on the thyroid independent pathway is not all-sided.This review aims to summarize the research progress of lipid metabo-lism regulation of iodine through three indirect pathways,including intestinal microbiota,oxidative stress and en-ergy metabolism.It will lay a foundation for the prevention and treatment of lipid metabolism related diseases.
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