首页|Development and Validation of Diagnostic Criteria for Elderly Atopic Dermatitis

Development and Validation of Diagnostic Criteria for Elderly Atopic Dermatitis

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Objective:Elderly atopic dermatitis(AD)is a newly identified subtype of AD.Whether specific diagnostic criteria are needed for elderly AD has been debated.This study aimed to propose diagnostic criteria for elderly AD and evaluate the sensitivity.Methods:A hospital-based study was conducted.We screened the clinical features of 1,312 patients with AD of different ages in 1 cohort and proposed a set of diagnostic criteria for elderly AD.The criteria were then validated in another cohort of 223 patients clinically diagnosed with elderly AD by dermatologists specialized in AD to examine the diagnostic sensitivity compared with other criteria by chi-square test.Results:Based on the patients'clinical features,a set of diagnostic criteria for elderly AD were proposed.The new diagnostic criteria showed significantly higher sensitivity than the classical diagnostic criteria(P＜0.001),especially for mild and moderate AD(P＜0.001).Of all 223 patients with elderly AD,93.3％fulfilled our criteria,while only 43.5％,65.5％,and 52.0％fulfilled the Hanifin and Rajka criteria,the Japanese Dermatology Academy criteria,and the United Kingdom Working Party criteria,respectively.Conclusion:The newly proposed criteria for elderly AD yielded high diagnostic sensitivity,particularly for mild and moderate AD.

atopic dermatitiselderlydiagnostic criteriasensitivityclinical featuresatypical

Shang-Shang Wang、Zheng Li、Chao-Ying Gu、Hui-Bin Yin、Yue-Meng Wu、Xu Yao、Wei Li

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Department of Dermatology,Shanghai Institute of Dermatology,Huashan Hospital,Fudan University,Shanghai 200040,China

Department of Allergy and Rheumatology,Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs,Hospital for Skin Diseases(Institute of Dermatology),Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing,Jiangsu 210042,China

国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家重点研发计划Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical SciencesClinical Research Plan of SHDCKey Project of the Innovation Program of Shanghai Municipal Education CommissionNanjing Incubation Program for National Clinical Research CenterKey Project of Social Development in Jiangsu Province

820033578200334981972939820734462022YFC36018002021-I2M-1-059SHDC220223022021-01-07-00-07-E000782019060001BE2020632

2024

10.1097/JD9.0000000000000349

国际皮肤性病学杂志
中华医学会,中国医学科学院皮肤病研究所

国际皮肤性病学杂志

CSTPCD
影响因子：0.276
ISSN：1673-4173
年,卷(期)：2024.7(1)
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