首页|Molecular Characteristics of Cephalosporin-Resistant Neisseria gonorrhoeae Strains in China:A Retrospective Study
Molecular Characteristics of Cephalosporin-Resistant Neisseria gonorrhoeae Strains in China:A Retrospective Study
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Objective:An increasing level of antimicrobial resistance to extended-spectrum cephalosporins has been reported,so we conducted this study to investigate the molecular characteristics of cephalosporin resistant Neisseria gonorrhoeae(NG)strains isolated from China Gonococcal Antimicrobial Resistance Surveillance Programme(China-GRSP).Methods:In total,2,038 NG isolates were collected from the China-GRSP between 2015 and 2016.NG multiantigen sequence typing(NG-MAST),multilocus sequence typing(MLST),and NG sequence typing for antimicrobial resistance(NG-STAR)were used to determine characteristics and resistant determinants of cephalosporin-resistant isolates.The results are described as percentages.Results:Seventy-four(3.6％)cephalosporin-resistant isolates were confirmed.MLSTSn363 was the most prevalent MLST among cefixime-resistant(CFX-R)isolates,whereas MLSTST7365(n=8)in was the most prevalent sequence type among ceftriaxone-resistant(CRO-R)isolates.CFX-R strains were mainly associated with penA-X(n=27,44.3％),penA-ⅩⅢ(n=6,9.8％),penA-ⅩⅧ(n=5,8.2％),and CRO-R strains were mainly related to penA-ⅩⅧ(n=10,25.6％),penA-43(n=9,23.1％),penA-ⅩⅢ(n=7,17.9％).Conclusion:The main conclusion of this study is that the predominant cephalosporin-resistant clones in China include locally emerged and imported linages.The CFX-R and CRO-R strains are primarily related to penA mutations,and their predominant genotypes are different.With the increase in international travel,tracking high-risk-resistant clones and identifying outbreaks and their associations with epidemiological characteristics are critical to improve public health.
Jin Zhang、Xiao-Yu Zhu、Jing-Wei Liu、Yue-Ping Yin、Shao-Chun Chen
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Reference Laboratory for STD Control,Hospital for Skin Diseases(Institute of Dermatology),Chinese Academy of Medical Sciences & Peking Union Medical College,Nanjing,Jiangsu 210042,China
National Center for STD Control,Chinese Center for Disease Control and Prevention,Nanjing,Jiangsu 210042,China
National Science and Technology Major ProjectJiangsu Provincial high level health personnel"six one project"top talent project
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