Abstract
Objective:An increasing level of antimicrobial resistance to extended-spectrum cephalosporins has been reported,so we conducted this study to investigate the molecular characteristics of cephalosporin resistant Neisseria gonorrhoeae(NG)strains isolated from China Gonococcal Antimicrobial Resistance Surveillance Programme(China-GRSP).Methods:In total,2,038 NG isolates were collected from the China-GRSP between 2015 and 2016.NG multiantigen sequence typing(NG-MAST),multilocus sequence typing(MLST),and NG sequence typing for antimicrobial resistance(NG-STAR)were used to determine characteristics and resistant determinants of cephalosporin-resistant isolates.The results are described as percentages.Results:Seventy-four(3.6％)cephalosporin-resistant isolates were confirmed.MLSTSn363 was the most prevalent MLST among cefixime-resistant(CFX-R)isolates,whereas MLSTST7365(n=8)in was the most prevalent sequence type among ceftriaxone-resistant(CRO-R)isolates.CFX-R strains were mainly associated with penA-X(n=27,44.3％),penA-ⅩⅢ(n=6,9.8％),penA-ⅩⅧ(n=5,8.2％),and CRO-R strains were mainly related to penA-ⅩⅧ(n=10,25.6％),penA-43(n=9,23.1％),penA-ⅩⅢ(n=7,17.9％).Conclusion:The main conclusion of this study is that the predominant cephalosporin-resistant clones in China include locally emerged and imported linages.The CFX-R and CRO-R strains are primarily related to penA mutations,and their predominant genotypes are different.With the increase in international travel,tracking high-risk-resistant clones and identifying outbreaks and their associations with epidemiological characteristics are critical to improve public health.
基金项目
National Science and Technology Major Project(2018ZX10101001-004-003)
Jiangsu Provincial high level health personnel"six one project"top talent project(LGY2019091)
NETL
NSTL
万方数据