Evaluating Early Nerve Injury and Its Relationship With Leprosy Reactions in Patients With Leprosy:A Prospective Cohort Study

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外文摘要：Objective:Leprosy is an infectious disease that can be accompanied by disability caused by peripheral neuropathy.Early detection of leprosy is essential to reduce its debilitating sequelae.Ultrasound is a noninvasive test that can detect nerve loss,but ultrasound measurement depends on the skill level of operators.Radiomics is an emerging field related to the extraction and quantification of information,which may provide new solutions for early detection of neuropathy caused by leprosy.This study aimed to combine radiomics and ultrasonography to evaluate nerve damage in the early stages of leprosy in China.Methods:Patients were enrolled at the Wenshan Prefecture Institute of Dermatology between October 2018 and December 2022.High-resolution ultrasound imaging of the peripheral nerves was performed.Quantitative ultrasound features were extracted from the images from 5 follow-ups.Radiomic features were selected for a comparative analysis of the disease course using a linear mixed-effects model to control for potential confounding effects.Results:Nine patients with leprosy were enrolled in this study,consisting of 5 males and 4 females with an average age of 34.44±13.58 years.With the change of treatment time,the ultrasound radiomics features of different parts of the linear mixed-effects model showed a trend of change:the nerve density(mean,skewness)was improved,the fascicular structure(kurtosis)was restored,and the abnormal morphological features in some parts were reduced(P＜0.05).Patients with type 1 leprosy reactions exhibited a lower mean and skewness,higher kurtosis,and increased quantitative morphological characteristics.Conclusion:The study provided the feasibility of ultrasound radiomics to digitally visualize the progression of nerve damage in leprosy patients.Ultrasound radiomics can be a low-cost method with high-throughput characteristics for clinical operators of different skill levels in early nerve injury detection of leprosy.

外文关键词：

leprosyultrasound radiomicsultrasoundnerve damage

作者：

Lan-Mei Lin、Hao Wu、Wan-Rong Zhu、Can-Bin Dong、Qi Zhang、Cheng-Hui Zheng、Xiao-Niu Liang、Heng Long、Jin-Hua Xu、Hong Ding、Juan Du

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作者单位：

Department of Dermatology,Huashan Hospital Affiliated with Fudan University,Shanghai 200040,China

Institute of Dermatology,Huashan Hospital Affiliated with Fudan University,Shanghai 200040,China

Wenshan Prefecture Institute of Dermatology,Wenshan,Yunnan 663000,China

The Smart Medicine and Al-based Radiology Technology(SMART)Laboratory,School of Communication and Information Engineering,Shanghai University,Shanghai 200444,China

Institute of Neurology,Huashan Hospital,Fudan University,Shanghai 200040,China

Department of Ultrasound,Huashan Hospital,Fudan University Shanghai 200040,China

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出版年：

2024

DOI：

10.1097/JD9.0000000000000402

国际皮肤性病学杂志

中华医学会,中国医学科学院皮肤病研究所

国际皮肤性病学杂志

CSTPCD

影响因子：0.276

ISSN：1673-4173

年,卷(期)：2024.7(4)