Abstract
In the past decade,there has been increasing interest in whether a widespread childhood varicella immunization scheme may increase the age-specific incidence of herpes zoster in adults.This proposition is based on evidence that exposure to endemic varicella boosts varicella-zoster virus-specific immunity in adults and that cessation of varicella in the community would result in a decline in the T-cell-mediated immunity required to maintain dormancy of varicella-zoster virus in neurons.However,numerous epidemiological studies have failed to fully explore this effect.Quantifying the efficacy of the varicella vaccine is a crucial step in understanding its benefits.We conducted this review to quantify the efficacy of the varicella vaccine(HZ/su vaccine)which will contribute immensely to our understanding of how the vaccine benefits the population in prevention against the herpes zoster,especially during the outbreak of Covid-19.
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