首页|长链非编码RNA MEG3对肿瘤细胞调控作用的研究进展

长链非编码RNA MEG3对肿瘤细胞调控作用的研究进展

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  • 国家科技期刊平台
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  • NSTL
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长链非编码RNA(long non-coding RNA，lncRNA)是一类长度超过200 nt的不编码蛋白的RNA分子。lncRNA最初被认为是转录噪音，在近年的研究中发现越来越多功能性的lncRNA，其重要性才渐渐被阐述。母系表达基因3(materally expressed gene 3，MEG3)是一种由母系印记基因编码的lncRNA，在对其功能的研究中发现MEG3几乎参与了所有的生理和病理过程，其在多种肿瘤中表现出抑制作用。本文就lnc RNA MEG3对肿瘤细胞调控的作用机制作一综述。
Research advancement of long non-coding RNA MEG3 in regulating tumor cell apoptosis
Long non-coding RNAs (lncRNAs) are deifned as RNA transcripts longer than 200 nucleotides which are not transcribed into a protein. In recent years, it was recognized that lncRNAs are not only transcriptional noise, but have important cellular functions. lncRNA are implicated in gene regulation through a variety of mechanisms. Maternally expressed gene 3 (MEG3) encodes an lncRNA which was suggested to function as a tumor suppressor. MEG3 almost involved in the physiological and pathological process. Here we review the role of lncRNA MEG3 in regulation of tumor cells, and discuss the molecule mechanism.

Long non-coding RNAmaternally expressed gene (MEG3)tumor

罗杨婧婷(综述)、唐圣松(审校)

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南华大学药物药理研究所，湖南 衡阳 421001

长链非编码RNA 母系表达基因3 肿瘤

湖南省高校科技创新平台开放基金湖南省高校科技创新平台开放基金

09K07212K120

2016

10.3978/j.issn.2095-6959.2016.02.013

临床与病理杂志
中南大学

临床与病理杂志

CSTPCD
影响因子：0.559
ISSN：1673-2588
年,卷(期)：2016.36(2)
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