Cell pyroptosis and related factors caspase-1,IL-1β,and non-small cell lung cancer
Cell pyroptosis is a programmed cell death process associated with inflammation,which occurs after mediation by caspase-1 and the pro-inflammatory factor interleukin1β(IL-1β),exerting a dual role in promoting or inhibiting the occurrence and development of non-small cell lung cancer(NSCLC).On the one hand,pyroptosis and related factors contribute to the progression of NSCLC by building a pro-tumor microenvironment.On the other hand,caspase-1 and IL-1β delay NSCLC progression by regulating the classical inflammatory pyroptosis pathway.In terms of lung tumor treatment,although some chemotherapy,immunotherapy,targeted therapy,and Chinese medicine therapy enhance drug sensitivity through the regulation of cell pyroptosis molecular mechanisms,delaying the progression of cancer cells,the surrounding normal tissues are also damaged due to adverse reactions caused by cell pyroptosis.To explore the role of caspase-1 and IL-1β as novel,independent biomarkers in the occurrence and treatment of NSCLC by inducing pyroptosis,and to provide a new theoretical basis and strategy for the targeted treatment of NSCLC.
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