KRAS-mutated mesonephric-like adenocarcinoma of ovary:A case report
Mesonephric-like adenocarcinoma(MLA)is a kind of adenocarcinoma mainly occurring in the endometrium and ovaries,displaying mesonephric-like differentiation,and characterized by strong invasiveness and a tendency to metastasize.Due to its complex and diverse microscopic manifestations,it is difficult to diagnose based solely on histological observations and requires assistance from immunohistochemistry and molecular biology detection for diagnosis.A case of primary ovarian MLA is reported.The patient,a 52-year-old female,presented to the Department of Gynecology of the Affiliated Hospital of Guizhou Medical University in October 2022 due to a pelvic mass detected by the color Doppler ultrasound examination at an external hospital.Intraoperatively,the right ovary was examined,and the frozen section diagnosis was adenocarcinoma of the right ovary.Subsequently,total hysterectomy,left adnexectomy,omentectomy,and pelvic lymph node dissection were performed.The pathological diagnosis revealed MLA of the right ovary with endometriosis;multiple uterine leiomyomas(intramural and subserosal type);and adenomyosis of the uterus.No metastatic carcinoma was found in the examined lymph nodes or omentum.The patient received six cycles of chemotherapy with paclitaxel combined with carboplatin.Follow-up until October 2023 indicated recurrence detected by two-dimensional ultrasound examination.
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