Expression of IL-13Rα2 in gastric cancer and precancerous lesions and its clinical significance
Objective:The long-term inflammatory microenvironment promotes atrophy,intestinal metaplasia,dysplasia of the gastric epithelium,and the occurrence of gastric cancer,but the mechanism is still unclear.This study aims to detect the expression of interleukin-13 receptor α2(IL-13Rα2)in gastric and precancerous lesions and explore its clinical significance.Methods:A total of 210 biopsies were divided into 5 groups:a chronic non-atrophic gastritis group(CNAG group,n=30),a chronic atrophic gastritis with intestinal metaplasia group(CAG/IM group,n=50),a low-grade dysplasia group(LGD group,n=30),a high-grade dysplasia group(HGD group,n=30),and a gastric cancer group(GC group,n=70).The expression of IL-13Rα2 in these groups was detected using the immunohistochemical EnVision two-step method.Additionally,the expression of IL-13Rα2 in 120 cases from radical gastric cancer surgery was analyzed to examine the relationship between IL-13Rα2 expression and the clinicopathological features of gastric cancer.Results:The positive rates of IL-13Rα2 expression in the CNAG,CAG/IM,LGD,HGD,and GC groups were 3.3%,42%,13.3%,6.7%,and 84.3%,respectively.Compared to the CNAG group,the positive expression rate of IL-13Ra2 in the CAG/IM group increased significantly(P<0.05).Compared to the CAG/IM group,the positive rates in the LGD and HGD groups decreased(both P<0.05),whereas it increased significantly in the GC group(P<0.001).In radical specimens,the positive expression rate of IL-13Rα2 in gastric cancer tissues was significantly higher than that in adjacent non-tumor tissues(P<0.001).Clinicopathological analysis showed that the positive expression of IL-13Rα2 in gastric cancer was related to Lauren classification,which was higher in intestinal type than that in diffuse,solid,and mixed types(all P<0.001).There was no significant correlation between IL-13Rα2 expression and the patient's age,gender,Helicobacter pylori infection status,clinical staging,or lymph node metastasis(all P>0.05).Conclusion:IL-13Rα2 shows weak positive expression in gastric intestinal metaplasia and strong positive expression in gastric cancer.IL-13Rα2 is highly expressed specifically in intestinal-type gastric cancer and holds promise as a new therapeutic target for gastric cancer.
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