摘要
心血管疾病是是当今人类病死的主要原因,哺乳动物心脏和血管细胞维持心血管系统的结构和稳态,因此细胞死亡对于心脏和血管稳态的发展至关重要.铁死亡是一种基于铁驱动的脂质过氧化机制的调节性细胞死亡,广泛参与了应激诱导的心脏和血管细胞的细胞死亡.在铁的催化下,细胞内脂质氢过氧化物代谢的紊乱导致谷胱甘肽过氧化物酶4失活,从而破坏氧化还原动态平衡,最终触发细胞死亡.氨基酸、铁、脂及其相关途径的代谢被认为是铁死亡的特异性生物标志物.铁死亡在动脉粥样硬化、主动脉夹层、动脉瘤、缺血再灌注、脑梗死、心力衰竭、心肌缺血再灌注损伤、心肌病、肺动脉高压、钙化性血管和瓣膜疾病等心血管疾病的病理、生理过程中起重要作用.
Abstract
Cardiovascular disease is a leading cause of morbidity and mortality in humans today.Maintenance of the structure and homeostasis of the cardiovascular system by mammalian cardiac and vascular cells makes cellular death crucial for the development of cardiac and vascular homeostasis.Ferroptosis is a regulatory form of cell death based on iron-driven lipid peroxidation mechanisms,widely involved in stress-induced cell death in cardiac and vascular cells.Under the catalysis of iron,disruption of lipid hydroperoxide metabolism within cells leads to inactivation of glutathione peroxidase 4,thereby disrupting oxidation-reduction homeostasis and ultimately triggering cell death.Metabolism of amino acids,iron,lipids,and related pathways are considered specific biomarkers for ferroptosis.Ferroptosis plays an important role in the pathophysiological processes of cardiovascular diseases such as atherosclerosis,aortic dissection,aneurysms,ischemia-reperfusion,ischemic stroke,heart failure,myocardial ischemia-reperfusion injury,cardiomyopathy,pulmonary hypertension,calcific vascular disease,and valvular diseases.
国家科技期刊平台
NSTL
万方数据