结直肠癌是消化道中较为常见的恶性肿瘤,其目前多采用手术切除的方式进行治疗,术后吻合口漏(anastomotic leakage,AL)是外科手术常见感染性并发症.术后发生AL会影响患者预期化学治疗时间,增加患者经济负担及二次手术可能,延长住院时长,加剧医患矛盾等.炎症指标可用于AL的早期预测,便于临床科室给予治疗方案.降钙素原(procalcitonin,PCT)是具有广泛生物学活性的多效性蛋白质,在结直肠癌术后AL的预测或排除中有重要作用,C-反应蛋白/血清白蛋白比值(C-reactive protein/serum albumin ratio,CAR)是反映全身炎症、免疫水平和营养状态的重要指标.二者均在早期对AL的预测有效,二者的联合应用可能存在更大的预测价值.
Procalcitonin and C-reactive protein/serum albumin ratio for predicting anastomotic leakage in postoperative patients with colorectal cancer
Colorectal cancer is a relatively common malignancy in the gastrointestinal tract,typically treated with surgical resection.Postoperative anastomotic leakage(AL)is a common infectious complication following surgery.The occurrence of postoperative AL can delay the anticipated timing of chemotherapy,increase economic burdens on patients,raise the likelihood of secondary surgery,prolong hospital stays,and intensify conflicts between medical staff and patients.Inflammation indicators can be used for the early prediction of AL,facilitating the development of treatment plans by clinical departments.Procalcitonin(PCT)is a pleiotropic protein with broad biological activity and plays an important role in predicting or ruling out AL after colorectal cancer surgery.The C-reactive protein/serum albumin ratio(CAR)is an important indicator that reflects systemic inflammation,immune level,and nutritional status.Both of them are effective in the early prediction of AL,and their combined use may offer greater predictive value.
colorectal canceranastomotic leakageprocalcitoninC-reactive protein/serum albumin ratio
国家科技期刊平台
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