具有多种恶性成分的子宫癌肉瘤1例
Uterine carcinosarcoma with multiple malignant components:A case report
龙婷 1张志尚 1李祖国 1王瑞安1
作者信息
- 1. 南方医科大学深圳医院病理科,广东深圳 518101
- 折叠
摘要
1例53岁同时具有多种恶性成分的子宫癌肉瘤患者,因"阴道流血伴下腹隐痛1年"入住南方医科大学深圳医院,妇科体格检查及影像学检查均提示宫体及宫颈占位,经宫颈组织病理活体组织检查确诊为宫颈恶性肿瘤,临床予术前新辅助化学治疗2次后,行宫颈癌根治手术治疗.术后病理诊断为子宫癌肉瘤,组织学显示肿瘤同时具有5种不同恶性成分,包括4种恶性上皮组织成分(子宫内膜样癌、鳞状细胞癌、神经内分泌癌和未分化癌)和1种恶性间叶组织成分(骨肉瘤).癌肉瘤是一种罕见的同时具有癌和肉瘤成分的双相性肿瘤,预后极差,明确诊断主要依赖组织病理学和免疫组织化学检查,手术是首选的治疗方法,术后需辅以化学治疗和/或放射治疗.
Abstract
A 53-year-old female patient with uterine carcinosarcoma containing multiple malignant components was admitted to Shenzhen Hospital of Southern Medical University due to"vaginal bleeding with lower abdominal pain for 1 year".Gynecological physical examination and imaging studies indicated masses in the uterine and cervix,cervical tissue biopsy confirmed the diagnosis of malignant cervical tumor.The patient received two rounds of neoadjuvant chemotherapy before undergoing radical surgery for cervical cancer.Postoperative pathological diagnosed uterine carcinosarcoma,histology showed that the tumor contained 5 different malignant components,including 4 malignant epithelial components(endometrioid carcinoma,squamous cell carcinoma,neuroendocrine carcinoma,undifferentiated carcinoma)and 1 malignant mesenchymal component(osteosarcoma).Carcinosarcoma is a rare biphasic tumor containing both carcinomatous and sarcomatous elements with a very poor prognosis.Accurate diagnosis mainly relies on histopathology and immunohistochemistry.Surgery is the preferred treatment method,followed by adjuvant chemotherapy and/or radiation therapy.
关键词
宫颈癌/癌肉瘤/双相性肿瘤Key words
cervical cancer/carcinosarcoma/biphasic tumor引用本文复制引用
基金项目
国家自然科学基金(81974441)
国家自然科学基金(81974441)
出版年
2024
国家科技期刊平台
NSTL
万方数据