Two cases of spermatic cord paraganglioma and literature review
Two patients were male,with case 1 being 69 years old and case 2 being 24 years old.Both presented for medical consultation due to a scrotal mass.Case 1 underwent a radical right orchiectomy,while case 2 underwent excision of the mass.Under the microscope,both cases showed tumor tissues arranged in nests and acinar patterns.The tumor cells were polygonal with abundant cytoplasm,eosinophilic or basophilic,and had deeply stained nuclei with evident nuclear atypia,though mitotic figures were rare.The stroma was rich in thin-walled blood vessels.The tumor cells expressed neuroendocrine markers such as synaptophysin(Syn),chromogranin A(CgA),and CD56,while the supporting cells around the tumor expressed S-100 protein.Post-surgery,the patients were followed up for 12 and 72 months respectively,with no recurrence or metastasis observed.Spermatic cord paraganglioma is relatively rare,and its diagnosis depends on histopathologic examination with genetic testing being advisable when necessary.Currently,all paragangliomas are classified as malignant tumors,and long-term follow-up observation is required after surgical removal.
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