Clinical characteristics and prognostic study of bloodstream infections caused by carbapenem-resistant Enterobacteriaceae
Objective:Bloodstream infections caused by carbapenem-resistant Enterobacteriaceae(CRE)have become a serious clinical challenge.This study aims to explore the clinical characteristics of hospital-acquired CRE bloodstream infections and the risk factors associated with mortality,providing a basis for infection control.Methods:Clinical data from patients with CRE bloodstream infections treated at Guangdong Provincial People's Hospital between January 2013 and December 2022 were collected to analyze the 28-day prognosis.Univariate and multivariate logistic regression analyses were applied to identify clinical risk factors for the prognosis of patients with CRE bloodstream infections.Results:Among 122 patients with CRE bloodstream infections,67 survived and 55 died.The pathogens identified were primarily Klebsiella pneumoniae,Escherichia coli,and Enterobacter cloacae.Univariate analysis suggested that age,underlying diseases,invasive procedures,use of antibiotics,and intensive care unit admission were significant risk factors for poor prognosis in CRE bloodstream infections(all P<0.05).Multivariate logistic regression analysis suggested that septic shock(OR=4.655,95%CI 1.118 to 19.385,P<0.05)was an independent risk factor for 28-day mortality in patients with CRE bloodstream infections.Conclusion:Patients with septic shock are more likely to develop CRE bloodstream infections.Clinicians should pay close attention to these patients,conduct early screenings,and effectively control the occurrence of bloodstream infections.
万方数据
维普
