Cyclooxygenase(COX)includes 2 isozymes:COX-1,which has a normal physiological protective function in the body,and COX-2,which mainly participates in analgesic and anti-inflammatory processes.COX-2 is an important mediator in myocardial ischemia-reperfusion injury(MI/RI),contributing to inflammation,atherosclerotic plaque formation,toxic shock,and cell apoptosis,leading to dysfunction and damage in multiple tissues.Non-steroidal anti-inflammatory effects are primarily associated with COX-2 inhibitors,therefore which can be used in the clinical treatment of MI/RI.
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