Analysis of differences between histopathological findings and endoscopic examination results in chronic atrophic gastritis
Objective:Some patients exhibit histopathological features of chronic atrophic gastritis that are not reported in corresponding endoscopic examinations.This study aims to investigate the clinical characteristics,pathological results,and the concordance rate with endoscopic findings in patients with histopathological evidence of atrophy and intestinal metaplasia,and to analyze the differences.Methods:The study collected data from January 2011 to December 2020 on gastroscopy and pathological diagnoses of chronic atrophic gastritis from the Third Xiangya Hospital and Changsha Central Hospital.Patients were divided into concordant and discordant groups based on the agreement between pathological and endoscopic results.Clinical characteristics,pathological findings,and differences in endoscopic results were compared between the 2 groups.Results:The study included 2446 patients with histopathological evidence of chronic atrophic gastritis,including 1472 males(60.2%),1829 cases(74.8%)with antral atrophy,and 1806 cases(73.8%)with intestinal metaplasia.The concordance rate between pathological and endoscopic diagnoses was 87.0%.There were differences in the distribution of lesions between the concordant and discordant groups(P<0.001).Among patients under 60 years old,the discordant groups had a younger age compared to the concordant group[(47.6±8.8)years vs(49.9±7.2)years,P<0.001].Conclusion:Chronic atrophic gastritis is more common in males,with atrophy mainly located in the antrum and most patients exhibiting intestinal metaplasia.Discrepancies between pathological and endoscopic findings are more frequent in non-antral regions and younger patients.
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