Extraskeletal myxoid chondrosarcoma with extensive hyaline cartilage differentiation:A case report
Extraskeletal myxoid chondrosarcoma(EMC)is a rare malignant mesenchymal tumor,constituting less than 1%of all soft tissue sarcomas.The median age of onset is around 50 years,with a male to female ratio of approximately 2꞉1.Classic EMC histology features translucent,gelatinous lobulated nodules with abundant light blue myxoid stroma,typically lacking mature hyaline cartilage components.Most EMC exhibit a t(9;22)(q22;q12)chromosomal translocation,leading to NR4A3 gene rearrangement,with the EWSR1-NR4A3 fusion gene being the most common.Classic EMC must be differentiated from chordoma,myxoid liposarcoma,myoepithelioma/myoepithelial carcinoma,and other myxoid tumors.On November 11,2020,Weihai Municipal Hospital treated a patient with a"left gluteal fat gap mass"identified by PET/CT.Post-surgical pathology and molecular testing confirmed a rare case of EMC with extensive hyaline cartilage differentiation.Clinicians should enhance their diagnostic skills for this EMC subtype to reduce misdiagnosis and missed diagnosis.
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