临床与病理杂志2024,Vol.44Issue(6) :819-826.DOI:10.11817/j.issn.2095-6959.2024.240175

新型冠状病毒感染疫情暴发前后荆门地区儿童社区获得性大叶性肺炎病原谱的变化

Changes in the pathogen spectrum of pediatric community-acquired lobar pneumonia in Jingmen area before and after the outbreak of COVID-19

刘金环 许华平 王晋妮 李清权
临床与病理杂志2024,Vol.44Issue(6) :819-826.DOI:10.11817/j.issn.2095-6959.2024.240175

新型冠状病毒感染疫情暴发前后荆门地区儿童社区获得性大叶性肺炎病原谱的变化

Changes in the pathogen spectrum of pediatric community-acquired lobar pneumonia in Jingmen area before and after the outbreak of COVID-19

刘金环 1许华平 1王晋妮 1李清权1
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作者信息

  • 1. 荆门市中心医院儿科,湖北荆门 448000;荆楚理工学院附属荆门市中心医院儿科,湖北 荆门 448000
  • 折叠

摘要

目的:儿童社区获得性大叶性肺炎是儿科常见的呼吸系统疾病之一,医疗资源消耗多,并发症多,针对其病原谱的治疗是关键.本研究旨在探讨新型冠状病毒感染疫情暴发前3年和后3年儿童社区获得性大叶性肺炎病原谱的变化,以期指导临床用药.方法:收集2017年1月1日至2023年1月8日在荆门市中心医院住院的820例社区获得性大叶性肺炎患儿的病例资料,分为疫情前组和疫情后组,比较2组的病原谱差异.结果:2组发病年龄、月份、病原阳性率及病原谱分布比较,差异均有统计学意义(均P<0.05),发病年龄上学龄期的占比明显下降,疫情后发病月份的波动幅度较疫情前小;病原学分布方面,疫情前组前3位依次为混合感染、单一支原体、单一细菌,疫情后组前3位依次为混合感染、单一细菌、单一支原体;2组细菌感染均以溶血性链球菌最多,疫情前组病毒感染以呼吸道合胞病毒占比最多,疫情后组以乙型流感病毒占比最多.结论:疫情暴发后,荆门地区儿童社区获得性大叶性肺炎患儿的病原谱发生了变化,细菌和乙型流感病毒占比明显升高.

Abstract

Objective:Pediatric community-acquired lobar pneumonia is a common respiratory disease in pediatrics,with high consumption of medical resources and frequent complications.Targeted treatment based on its pathogen spectrum is crucial.This study aims to investigate the changes in the pathogen spectrum of pediatric community-acquired lobar pneumonia 3 years before and 3 years after the outbreak of coronavirus disease 2019(COVID-19),with the goal of providing guiding clinical medication.Methods:Clinical data were collected from 820 pediatric patients with community-acquired lobar pneumonia hospitalized at Jingmen Central Hospital from January 1,2017,to January 8,2023.The cases were divided into a pre-pandemic group and a post-pandemic group,and the differences in pathogen spectrum between the 2 groups were compared.Results:Significant differences were observed between the 2 groups in terms of age of onset,month of onset,pathogen positivity rate,and distribution of the pathogen spectrum(all P<0.05).The proportion of school-aged children decreased significantly,and the fluctuations in the month of onset were smaller post-pandemic compared to pre-pandemic.In terms of pathogen distribution,the top 3 in the pre-pandemic group were mixed infections,single mycoplasma infections,and single bacterial infections,while in the post-pandemic group,they were mixed infections,single bacterial infections,and single mycoplasma infections.Streptococcus was the most common bacterial infection in both groups.Respiratory syncytial virus was the most common viral infection pre-pandemic,while influenza B virus was the most common post-pandemic.Conclusion:After the COVID-19 outbreak,the pathogen spectrum of pediatric community-acquired lobar pneumonia in the Jingmen area has changed,with a significant increase in the proportion of bacterial and influenza B virus infections.

关键词

儿童/大叶性肺炎/病原谱

Key words

children/lobar pneumonia/pathogen spectrum

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基金项目

湖北省卫生健康委科研项目(WJ2021F085)

出版年

2024
临床与病理杂志
中南大学

临床与病理杂志

CSTPCD
影响因子:0.559
ISSN:1673-2588
参考文献量16
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