骨质疏松(osteoporosis,OP)是由多种因素诱导、致使骨组织纤维结构受损、骨脆性增加、骨折概率明显增加的慢性进行性疾病.绝经后女性雌激素分泌减少可通过多种途径影响骨代谢平衡.2型糖尿病(Type 2 diabetes mellitus,T2DM)并发OP与骨折风险增加有一定的相关性,一方面血糖高于正常参考值会加速晚期糖基化终末产物(advanced glycation end products,AGEs)在循环及骨组织中的堆积,导致骨代谢紊乱;另一方面高血糖状态可抑制骨自噬,从而影响骨细胞凋亡.但目前绝经后T2DM并发OP的机制尚未完全明确,治疗上缺乏协调性.因此,深入了解绝经后T2DM妇女易发OP的发病机制,完善早期骨折风险的诊断方法,可为绝经后T2DM并发OP的精准治疗提供新思路.
Mechanism and prevention of osteoporosis in postmenopausal patients with Type 2 diabetes mellitus
Osteoporosis(OP)is a chronic and progressive disease induced by multiple factors,leading to damage in the fibrous structure of bone tissue,increased bone fragility,and a significantly higher risk of fractures.In postmenopausal women,the reduction in estrogen secretion can affect bone metabolic balance through various pathways.There is a certain correlation between Type 2 diabetes mellitus(T2DM)and the increased risk of OP and fractures.On one hand,the blood glucose levels higher than normal accelerate the accumulation of advanced glycation end products(AGEs)in circulation and bone tissue,resulting in disrupted bone metabolism.On the other hand,hyperglycemia can inhibit bone autophagy,thereby affecting osteocyte apoptosis.However,the mechanisms underlying the comorbidity of T2DM and OP in postmenopausal women are not yet fully understood,and treatment lacks coordination.Therefore,a deeper understanding of the mechanisms that make postmenopausal women with T2DM prone to developing OP,along with improved methods for early fracture risk diagnosis,can provide new insights for the precise treatment of OP comorbid with T2DM in clinical practice.
postmenopauseType 2 diabetes mellitusbone metabolismosteoporosisprevention and treatment
万方数据
维普
