Defects in DNA damage response and high-risk neuroblastoma
Neuroblastoma(NB)is the most common extracranial solid tumor in children,with the high-risk patients characterized by rapid progression and poor prognosis.Molecular genetics reveal that high-risk NB is typically marked by chromosomal instability,primarily due to defects in the DNA damage response(DDR).Currently,targeted DDR inhibitors,such as ATR,ATM,PARP,CHK1,and WEE1 inhibitors,are being used in the treatment of high-risk NB.The application of DDR defects and targeted inhibitors in high-risk NB offers a reference for precise diagnosis and treatment,potentially providing a new strategy for treating high-risk NB.
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