Co-expression of TTF-1 and P40 in 2 cases of non-small cell lung carcinoma and literature review
The clinicopathological characteristics of 2 cases of non-small cell lung cancer(NSCLC)co-expressing thyroid transcription factor-1(TTF-1)and protein 40(P40),were analyzed.Both patients were elderly males with a long history of smoking and presented with respiratory symptoms such as chest tightness,chest pain,and cough.CT scans indicated lung cancer.Microscopic examination revealed tumor cells arranged in nests with squamous epithelial differentiation features,including visible cell boundaries and intercellular connections but no glandular structures or mucus.Immunohistochemical analysis showed diffuse strong positivity for cytokeratin 7(CK7),TTF-1,CK5/6,P40,and P63,while protein P53 exhibited a mutant expression pattern.Both cases lacked expression of integrase interactor-1(Ini-1)and core catalytic subunit of the chromatin remodeling complex,brahma-related gene 1(BRG-1),with elevated Ki-67.Both cases also had tumor protein 53(TP53)gene mutations.NSCLC with simultaneous adenocarcinomatous and squamous differentiation is extremely rare.Of the 12 reported cases of NSCLC co-expressing TTF-1 and P40,including this study,10 cases have detected TP53 gene mutations.Due to the limited number of cases,the 2021 World Health Organization classification for the thoracic tumors has not provided specific diagnostic subtypes or prognostic recommendations,indicating a need for further case reports.
non-small cell lung carcinomathyroid transcription factor-1protein 40immunohistochemistryco-expressiontumor protein 53
万方数据
维普
