Objective:Nephrotic syndrome(NS)is a common glomerular disease with various pathological types and is often associated with thyroid dysfunction in clinical practice.This study aims to analyze the pathological characteristics of NS patients with thyroid dysfunction.Methods:A total of 499 NS patients who were admitted to the Department of Nephrology at Yichang Central People's Hospital from January 2015 to December 2021 and underwent renal biopsy were selected.Based on thyroid function test results,the patients were divided into a normal thyroid function group(n=187)and a thyroid dysfunction group(n=312);based on etiology,they were categorized into a primary nephrotic syndrome(PNS)group and a secondary nephrotic syndrome(SNS)group.Relevant clinical data were collected to analyze the relationships between the clinical indicators and thyroid function,the renal pathology types and thyroid dysfunction,and differences in thyroid function between PNS and SNS.Results:1)In the 499 NS patients,there were significant differences in gender,hospital stay,24-hour urinary protein excretion(24 h-UTP),albumin(Alb),free triiodothyronine(FT3),and free thyroxine(FT4)between the normal group and the thyroid dysfunction group(all P<0.05);2)the membranous nephropathy was the most common pathological type in the thyroid dysfunction group(P<0.05),with minimal change disease(MCD)showing the highest probability of thyroid dysfunction(P<0.05).Subclinical hypothyroidism was most prevalent in the PNS group(39.19%),while the euthyroid sick syndrome was most common in the SNS group(47.78%),with both showing significant differences(both P<0.05).Conclusion:The proportion of thyroid dysfunction varies with different renal pathological types in the NS patients,and there is difference in the clinical phenotypes of thyroid dysfunction between PNS and SNS.
关键词
肾病综合征/甲状腺功能减退/正常甲状腺功能病态综合征/病理类型
Key words
nephrotic syndrome/hypothyroidism/euthyroid sick syndrome/pathological type
万方数据