Mechanism of irisin in arteriosclerosis obliterans
Arteriosclerosis obliterans(ASO)is an atherosclerotic disease primarily affecting large and medium-sized arteries.Its incidence is increasing yearly,significantly impairing patients'quality of life and potentially leading to amputation or death.Irisin,a peptide induced by exercise,plays a role in thermogenesis and metabolic regulation,and it alleviates the pathophysiological processes of ASO through multiple mechanisms.These include promoting endothelial cell proliferation and repair,inhibiting oxidative stress and chronic inflammatory responses,regulating lipid metabolism,and improving dyslipidemia.Additionally,irisin exhibits antioxidant properties in nicotine-induced vascular injury models,mitigates the phenotypic transformation of vascular smooth muscle cells,and reduces atherosclerotic plaque formation.These diverse mechanisms highlight irisin's potential in ameliorating the pathological procession of ASO.Although most current studies focus on basic research,further clinical validation is needed to assess its effectiveness and safety in clinical applications.Nonetheless,these findings provide a theoretical basis for developing irisin-based interventions,offering new insights for improving ASO patient outcomes.
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