Exploring the Impact and Mechanisms of Lipid Metabolism Dysregulation on Ferroptosis in Alzheimer's Disease
Alzheimer's disease(AD)is a common neurodegenerative disorder characterized by severe memory loss and cognitive decline.However,its pathogenesis is complex and not fully understood.Recent research has highlighted ferroptosis,a form of programmed cell death driven primarily by intracellular iron overload and subsequent lipid peroxidation,as playing a critical role in the onset and progression of AD.Dysregulation of lipid metabolism in AD significantly influences cellular sensitivity to ferroptosis.This review discusses how lipid metabolism dysregulation modulates ferroptosis in Alzheimer's disease,including the effects of abnormal lipid synthesis,increased lipid peroxidation,altered lipid storage and degradation,and reduced lipid β-oxidation on ferroptosis sensitivity.Additionally,the review explores the potential therapeutic effects of common antioxidants in regulating ferroptosis.These discussions provide a crucial theoretical foundation for a deeper understanding of AD pathogenesis and the development of novel therapeutic strategies.
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