Objective To explore the relationship between age-adjusted Charlson co-morbidity index(ACCI)and the prognosis of patients with dementia.Methods A retrospective analysis of the clinical data of dementia patients admitted to a tertiary hospital in Zhongshan city from January 2018 to July 2023 was conducted.The patients'comorbidities and prognosis were organized,and the ACCI scores were calculated and categorized.The predictive ability of ACCI for the prognosis of dementia patients was assessed using the receiver operating characteristic(ROC)curve.Results A total of 993 patients with dementia were included,with an average age of(79.67±8.21)years,and 159 patients(16%)died.The top three comorbidities were cerebrovascular disease in 291 cases(29.3%),chronic pulmonary disease in 289 cases(29.1%),and diabetes without organ damage in 280 cases(28.2%),whereas no statistical difference were observed between different age groups,genders,types of dementia,or levels of depression(P＞0.05).Multivariate Cox regression analysis showed that ACCI score and depression were independent predictors of prognosis in patients with dementia(P＜0.05).The death risk of patients with a high ACCI score was 3.313 times higher than that patients with a low score(HR=3.313,95%CI=1.037～10.582),and the death risk of patients with an extremely high score was 13.154 times higher than that of patients with a low score(HR=13.154,95%CI=4.033～43.901).The area under the ROC curve of ACCI in predicting all-cause mortality risk in patients with dementia was 0.769,indicating a certain predictive value for mortality risk.Conclusions Dementia patients generally have multiple complications,and the ACCI score is associated with their prognosis.The higher the ACCI score,the worse the prognosis of patients.
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