Objective To explore the practical effects of BOPPPS blended learning model based on cloud classroom in Hospital Management Practice courses.Methods 80 students majoring in health information management from Jiangsu Health Vocational College in 2021 were selected as the control group,receiving traditional teaching methods;82 students in 2022 were selected as the experimental group,and BOPPPS blended learning based on cloud classroom was adopted.The results of course assessment and questionnaire survey of the two groups were compared.Results The score of final assessment in the experimental group students was 81.34±4.99,significantly higher than that of the control group students 75.14±5.38(P<0.001);the satisfaction of the experimental group students in terms of teaching methods,teacher instruction,learning outcomes,and active learning ability improvement were higher than those of the control group( P<0.05);the scores of self-management,group cooperation,learning initiative and information literacy in the experimental group were higher than those before teaching(P<0.05).Conclusions The BOPPPS blended learning model based on cloud classroom can effectively stimulate students' learning enthusiasm and initiative,and improve teaching quality and learning effectiveness.