Pathogen spectrum analysis in suspected measles cases in Shanghai from 2014 to 2019
To explore the pathogen spectrum in suspected measles cases in Shanghai from 2014 to 2019,1 197 pharyngeal swab specimens were collected from 3 325 measles/rubella negative speciments and screened to detect eleven rash fever associated viruses,including varicella-zoster virus,human parvovirus B19,HSV-1,HHV-6,HHV-7,EBV and other enteroviruses by real time PCR.A total of 9 viruses were detected,and the virus detection rate was 9.7％(108/1 197).Mixed infection was not detected.The positive rate of human Epstein-Barr virus was the highest(1.8％),followed by HHV-6(1.7％),varicella-zoster virus and human parvovirus B19(1.3％respectively).The positive rate of other EV was 0.8％.CA6 and CA10 were found in 7 cases with a positive rate of 0.6％,respectively.HSV-1 was found in 6 cases,and the positive rate was 0.5％.4 cases were CA16,and the positive rate was 0.3％.Human parvovirus B19 and VZV were mainly detected in children.EB,HHV-6,CA16 and CA6 were detected in adults and children at similar rates.Human parvovirus B19 and other enteroviruses were mainly detected in adult cases.VZV,EBV and HHV-6 were mainly detected in males,and HSV-1 was mainly detected in females.In addition to measles and rubella,9 viruses including EBV,HSV-1 and human parvovirus B19,may cause fever and rash symptoms and be clinically diagnosed as measles.More attention should be paid to the clinical diagnosis.
MeaslesSuspected casesRash and fever illnessPathogen spectrumPCR
NETL
NSTL
万方数据
