To explore the pathogen spectrum in suspected measles cases in Shanghai from 2014 to 2019,1 197 pharyngeal swab specimens were collected from 3 325 measles/rubella negative speciments and screened to detect eleven rash fever associated viruses,including varicella-zoster virus,human parvovirus B19,HSV-1,HHV-6,HHV-7,EBV and other enteroviruses by real time PCR.A total of 9 viruses were detected,and the virus detection rate was 9.7％(108/1 197).Mixed infection was not detected.The positive rate of human Epstein-Barr virus was the highest(1.8％),followed by HHV-6(1.7％),varicella-zoster virus and human parvovirus B19(1.3％respectively).The positive rate of other EV was 0.8％.CA6 and CA10 were found in 7 cases with a positive rate of 0.6％,respectively.HSV-1 was found in 6 cases,and the positive rate was 0.5％.4 cases were CA16,and the positive rate was 0.3％.Human parvovirus B19 and VZV were mainly detected in children.EB,HHV-6,CA16 and CA6 were detected in adults and children at similar rates.Human parvovirus B19 and other enteroviruses were mainly detected in adult cases.VZV,EBV and HHV-6 were mainly detected in males,and HSV-1 was mainly detected in females.In addition to measles and rubella,9 viruses including EBV,HSV-1 and human parvovirus B19,may cause fever and rash symptoms and be clinically diagnosed as measles.More attention should be paid to the clinical diagnosis.
MeaslesSuspected casesRash and fever illnessPathogen spectrumPCR
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