Detection rate of carbapenem-resistant Pseudomonas aeruginosa in a tertiary hospital and the correlation between the frequency of carbapenem-resistant antimicrobial drugs
This study investigated the clinical distribution of carbapenem-resistant pseudomonas aeruginosa(CRPA)in a tertiary hospital,and the correlation ship between the CRPA detection rate and(defined daily doses,DDDs)of carbapenem antibiotics,so as to provide basis for clinical treatment,prevention and control of hospital infection and rational use of antibacterial drugs.The data of clinical strains isolated from the hospital from 2017 to 2021 were analyzed by WHONET 5.6 and SPSS 23.0 software.Results displayed that 622 pseudomonas aeruginosa(PA)were isolated from the hospital from 2017 to 2021,including 91 CRPA,with a detection rate of 14.63%.Departments distribution of CRPA were mainly in respiratory and critical care medicine(31.87%),intensive care unit(23.08%)and neurosurgery(18.68%).Among the main specimen types,sputum and alveolar lavage fluid accounted for 81.32%,followed by wound secretion and urine,accounting for 6.59%and 5.49%,respectively.For the age distribution,≥80 years old(25.27%)and 60-79 years old(29.67%)was the most common.According to DDDs analysis results,the detection rate of CRPA from 2017 to 2021 was positively correlated with DDDs(r=0.82,P=0.086).In clinical departments,the detection rate of CRPA in neurosurgery was positively correlated with DDDs(r=0.78,P=0.122).There is a positive correlation ship between CRPA isolated in the hospital and DDDs of carbapenem antibiotics.In order to avoid the occurrence of common infection and resistance of colonized bacteria,antimicrobial management should be further strengthened to promote rational clinical drug use.
Carbapenem-resistant Pseudomonas aeruginosaDetection rateDefined daily doses of carbapenemCorrelation ship
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