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小型无绿藻引起的多发性皮肤感染1例

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本文报道了1例经由小型无绿藻(Prototheca wickerhamii)所致的多处皮肤严重感染病例.通过对患者右手背糜烂处深部皮肤组织样本进行培养,在35℃体积分数5%CO2环境中培养48 h后于血平板上可见白色干燥菌落生长,经革兰氏染色油镜下可见呈紫色球形或卵球形菌体.念珠菌显色平板上可见浅紫色奶油样菌落生长,经乳酸酚棉兰和钙荧光白荧光染色后于油镜下均可见桑葚胚状的内生孢子,最后该菌经VITEK 2-Compact全自动微生物鉴定分析系统及VITEK MS质谱仪鉴定为小型无绿藻(P.wickerhamii).临床医生根据病情及药敏试验结果,先后使用伏立康唑及伊曲康唑进行抗真菌治疗,病人皮疹明显好转并顺利出院.
Multiple severe skin infection caused by Prototheca wickerhamii:a case report
The present paper reported a case of multiple severe skin infection caused by Prototheca wickerhamii(P.wickerhamii).By culturing the deep skin tissue at the erosion site of the patient's right hand back,white dry colonies could be seen growing on the blood plate after 48 h of cultivation at 35℃and 5%CO2.Purple spherical or oval shaped bacteria bodies could be seen under the gram staining oil microscope.Light purple creamy colonies were observed on the candida colorimetric plate.After staining with lactophenol cotton blue and calcofluor white,endogenous spores resembling mulberry embryos could be seen under the oil microscope.Finally,this strain was identified as P.wickerhamii by the VITEK 2-Compact fully automatic microbial identification analysis system and VITEK MS mass spectrometer.The patient was given voriconazole and itraconazole for antifungal treatment based on his condition and drug sensitivity results.The patient's rash improved significantly and was discharged smoothly.

Prototheca wickerhamiiProtothecosisSkin infection

刘佳星、刘娅汀、孟玲宁、徐学静、郭建、张燕

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南京大学医学院附属鼓楼医院检验科,江苏 南京 210008

南通大学公共卫生学院,江苏 南通 226019

上海市东方医院南院检验科,上海 200120

小型无绿藻 无绿藻病 皮肤感染

2024

微生物与感染
复旦大学

微生物与感染

CSTPCD
影响因子:0.594
ISSN:1673-6184
年,卷(期):2024.19(2)