Objective This paper aims to analyze the prevalence and susceptibility factors of fatty liver among male non-manual workers in Shanghai,and provide reference for the prevention and treatment of fatty liver in this population.Methods A total of 16 959 male non-manual workers who underwent physical examinations at the Health Management Center of Huadong Sanatorium from January 2023 to December 2023 were selected as the research subjects,and their basic data,laboratory indicators,and imaging examination results were collected.Single factor and multivariate analysis were conducted to explore the susceptibility factors of fatty liver.The ROC curve was used to analyze the predictive value of various indicators for fatty liver disease.Results The detection rate of fatty liver in male non-manual workers in Shanghai is 55.97%,and it shows an increasing trend with age,with a slight decrease in those over 60 years old.Physical exercise is a protective factor for fatty liver.Age,obesity,smoking,drinking,unbalanced diet,hypertension,diabetes,hypertriglyceridemia,hyperuricemia(HUA),and impaired fasting glucose(IFG)are susceptible factors for male non-manual workers in Shanghai to suffer from fatty liver.Unbalanced diet and diabetes have a high predictive value for male non-manual workers in Shanghai to suffer from fatty liver,and IFG has the highest predictive value.Conclusions The detection rate of fatty liver in male non-manual workers in Shanghai is high,and increases with age.Physical exercise is the protective factor while age,obesity,smoking,drinking,unbalanced diet,hypertension,diabetes,hypertriglyceridemia,HUA,and IFG are susceptible factors,among which,unbalanced diet,diabetes,and IFG have a high predictive value for their fatty liver.