Objective This paper intends to explore the clinical value of serum chemokine CC motif ligand 16(CCL16)in predicting the prognosis of patients with decompensated hepatitis B cirrhosis.Methods A hundred patients with decompensated hepatitis B cirrhosis admitted to 3201 Hospital from September 2021 to September 2022 were selected as the study subjects.According to the Child-Pugh score and grading criteria,the patients were divided into the Child-Pugh A group(n=30),the Child-Pugh B group(n=38),and the Child-Pugh C group(n=32).Based on the 6-month follow-up prognosis,the patients were assigned into the survival group(n=58)and the death group(n=42).The serum CCL16 levels and other related indicators of each group were compared.The logistic regression analysis was conducted to explore the factors affecting the prognosis of patients with decompensated hepatitis B cirrhosis.The ROC curve analysis was performed to predict the prognostic efficacy of serum CCL16 in patients with decompensated hepatitis B cirrhosis.Results The serum CCL16 levels in the Child-Pugh A group,the Child-Pugh B group,and the Child-Pugh C group decrease sequentially,with a statistically significant difference(P＜0.05).Compared with the survival group,the white blood cell count,the HBV-DNA,the TBil level,and the Child-Pugh score are significantly increased,while the serum CCL16 level is significantly decreased(P＜0.05).The results of multivariate logistic regression analysis shows that the serum CCL16,the white blood cell count,the HBV-DNA,the TBil level,and the Child-Pugh scores are influencing factors for the prognosis of patients with decompensated hepatitis B cirrhosis(P＜0.05).The ROC curve analysis indicates that the area under the curve(AUC)of serum CCL16 predicting the prognosis of patients with decompensated hepatitis B cirrhosis is 0.921,with a specificity of 97.62%and a sensitivity of 74.14%.Conclusions The serum CCL16 level is closely related to the severity and prognosis of patients with decompensated hepatitis B cirrhosis.It significantly decreases with the severity of the patient's condition,and its predictive power for patient prognosis is high.
Chemokine CC motif ligand 16Hepatitis B cirrhosisDecompensationPrognosisClinical value
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