Objective This paper intends to analyze the endoscopic and pathological characteristics of colorectal polyps in patients with chronic HBV infection,and explore their cancer risk and difficulty in endoscopic treatment.Methods A hundred and forty-seven patients who underwent endoscopic polypectomy at Chengde Central Hospital from January 2019 to December 2022 were selected as the study subjects.Fifty-three patients with HBV infection were assigned to the HBV group,and ninety-four patients without HBV infection were assigned to the control group.The basic information of the patient,as well as data on serum carcinoembryonic antigen(CEA)testing,endoscopic,and pathological examination results upon admission,were collected.The polyp detection rate,endoscopic and pathological characteristics,endoscopic treatment time,intraoperative and postoperative bleeding rates,and serum CEA levels of each intestinal segment in two groups were compared.Results The detection rate of rectal polyps in the HBV group is significantly higher than that in the control group(43.40%versus 25.53%,and P=0.026).The maximum diameter,number,pedicle rate,endoscopic treatment time,intraoperative bleeding rate,and serum CEA level of the HBV group are significantly higher than those of the control group(P<0.05).The incidence of adenomatous polyps and cancerous polyps in the HBV group is significantly higher than that in the control group(92.45%versus 70.21%,and P=0.002).Conclusions Compared with the general population,patients with chronic HBV infection complicated by colorectal polyps have a higher detection rate of rectal polyps.The pathological examination results are mostly adenomatous polyps or cancerous polyps,which have a higher risk of cancerous transformation.Polyps are often large,pedicled,and frequent,with a high intraoperative bleeding rate.Endoscopic treatment is difficult and the risk of complications is high.Early screening is recommended.