Objective This paper intends to investigate the effect of Clostridium butyricum capsule combined with itopride on gastrointestinal hormones in patients with functional dyspepsia(FD).Methods A total of 82 FD patients who were admitted to Xidian Group Hospital from November 2021 to December 2022 were randomly assigned to the observation group(n=41)and the control group(n=41).The control group was treated with itopride hydrochloride,while the observation group was treated with Clostridium butyricum capsule combined with itopride hydrochloride.All patients were treated continuously for 3 months.The 7-score global symptom scale(GOSS)and functional digestive disorder quality of life scale(FDDQL)were used to evaluate the clinical symptoms and quality of life before and after treatment.The expression levels of serum gastrin(GAS),5-hydroxytryptamine(5-HT),and motilin(MLT)were detected by using the radioimmunoassay method.The clinical effective rates of the two groups after 3 months treatment were compared.Results After 3 months of treatment,the scores of GOSS and the levels of 5-HT in both groups decrease,while the scores of FDDQL,and the levels of GAS and MLT increase,with statistically significant differences(P＜0.05).After 3 months of treatment,the scores of GOSS and the levels of 5-HT in the observation group are lower than those in the control group,while the scores of FDDQL,and the levels of GAS and MLT are higher than those in the control group,with statistically significant differences(P＜0.05).After 3 months of treatment,the clinical effective rate of the observation group is 95.12%,which is higher than that of the control group(78.05%),with a statistically significant difference(P＜0.05).Conclusions Clostridium butyricum capsule combined with itopride can effectively relieve the digestive tract symptoms of FD patients,improve the gastrointestinal peristalsis function and clinical efficacy,which is beneficial to improving the quality of life of FD patients.It has a certain value of clinical promotion.
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