Objective This paper is to investigate the correlation between serum fibronectin typeⅢ domain 5(FNDC5)and complement C1q/tumor necrosis factor-related protein 12(CTRP12)expression levels with glucose and lipid metabolism and liver function in patients with metabolic-related fatty liver disease(MAFLD).Methods A total of 100 patients with MAFLD admitted to Honghu Maternal and Child Health Hospital and Xiangyang Central Hospital from June 2019 to June 2022 were selected and assigned to the MAFLD group,and 100 healthy individuals who were examined in the medical examination center of Honghu Maternal and Child Health Hospital during the same period were selected and assigned to the control group.The serum FNDC5 and CTRP12 levels were detected by ELISA.The correlation between serum FNDC5,CTRP12,glucose and lipid metabolism,and liver function in MAFLD patients was analyzed by Pearson correlation analysis.The ROC curve was performed to analyze the diagnostic value of serum FNDC5 and CTRP12 for MAFLD.The logistic regression analysis was conducted to explore the risk factors affecting the occurrence of MAFLD.Results The levels of ALT,AST,ALB,HDL-C,LDL-C,TC,TG,FBG,FINS,and HOMA-IR in the MAFLD group are higher than those in the control group,with statistically significant differences(P＜0.05).Compared with the control group,the MAFLD group has an increase in serum FNDC5 levels and a decrease in serum CTRP12 levels,with statistically significant differences(P＜0.05).The Pearson correlation analysis results show that the serum FNDC5 levels in patients are positively correlated with ALT,FBG,TG,FINS,and HOMA-IR(r=0.504,0.496,0.474,0.418,0.501,and P＜0.05),while the serum CTRP12 levels in patients are negatively correlated with ALT,FBG,TG,FINS,and HOMA-IR(r=-0.496,-0.421,-0.403,-0.425,-0.496,and P＜0.05).The results of ROC curve analysis show that the area under the curve(AUC)of serum FNDC5 combined with CTRP12 in the diagnosis of MAFLD is 0.860,which is greater than that of single detection.In addition,the sensitivity and specificity of combined detection are higher than those of single detection.The results of the multiple logistic regression model analysis show that TG,HOMA-IR,and FNDC5 are risk factors for MAFLD,and serum CTRP12 is a protective factor(P＜0.05).Conclusion The upregulation of serum FNDC5 and downregulation of serum CTRP12 in patients with MAFLD are closely related to the indexes of glucose and lipid metabolism and liver function,and may be a biomarker for the diagnosis of MAFLD.
Metabolic associated fatty liver diseaseFibronectin type Ⅲ domain-containing 5Complement C1q/tumor necrosis factor-related protein 12Glycolipid metabolismLiver function
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