Analysis of predictive efficacy of peripheral blood leukocyte differentiation antigen 38 and IL-22 expression in development of cirrhosis in patients with autoimmune hepatitis
Objective This paper attempts to explore the predictive efficacy of peripheral blood leukocyte differentiation antigen 38(CD38)and IL-22 for the development of cirrhosis in patients with autoimmune hepatitis(AIH).Methods A total of 93 AIH patients admitted to the Third People's Hospital of Chengdu from May 2019 to May 2022 were selected as the research subjects.The patients were divided into the non-cirrhosis group(n=75)and the cirrhosis group(n=18)based on whether they developed cirrhosis,whose general information and serum CD38 and IL-22 expression levels were compared.The logistic regression analysis was conducted to explore the risk factors of cirrhosis.The ROC curve was performed to analyze the predictive value of serum CD38 and IL-22 for the development of cirrhosis.Results Among the 93 AIH patients,there are 18 cases of cirrhosis and 75 cases of non-cirrhosis.Compared with the non-cirrhotic group,the serum CD38 and TBil levels in the cirrhotic group are higher,while the IL-22 level is lower,with statistically significant differences(P＜0.05).The results of multiple logistic regression model analysis show that serum CD38,TBil,and IL-22 are all independent risk factors for AIH induced cirrhosis(P＜0.05).The ROC curve analysis results show that the combined detection of serum CD38 and IL-22 prediction of the area under the curve(AUC)of AIH induced cirrhosis is 0.849,which is larger than that of single detection,and the specificity of the combined detection is the highest.Conclusion The expression of serum CD38 is upregulated and the expression of serum IL-22 is downregulated in patients with AIH complicated with cirrhosis,and the combined detection of both has a certain clinical reference value for predicting the occurrence of cirrhosis in the AIH patients.
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