Objective This paper intends to analyze clinical pathological characteristics of fundic gland polyp(FGP)and their correlation with the expression of estrogen receptor α(ERα),ERβ,and progesterone receptor(PR)in FGP tissues.Methods Five hundred and thirty-four patients who underwent gastroscopy and were diagnosed with FGP by histopathology at the Second Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology from May 2021 to October 2022 were selected and assigned to the FGP group,while a hundred and seventy-five patients who underwent gastroscopy and were diagnosed with chronic non-atrophic gastritis by histopathology during the same period were selected and assigned to the control group,whose clinical data were collected.The FGP tissues of 42 patients and chronic non-atrophic gastritis tissue paraffin specimens of 22 patients were randomly selected,and the expression levels of ERα,ERβ,and PR in the tissues were detected by immunohistochemistry.Multivariate logistic regression analysis was used to explore the influencing factors of FGP occurrence.Spearman rank correlation was used to explore the correlation between ERα,ERβ,and PR expression in FGP tissues.Results The diameter of most FGPs are less than 0.5 cm(71.5%).Multiple polyps(62.0%)are more common than single polyps(38.0%).The most common site of occurrence is the stomach body(362 cases(67.8%),followed by the stomach fundus+stomach body(98 cases(18.4%)).The morphology of polyps is mainly Yamada type Ⅰ(65.1%)and type Ⅱ(34.3%).FGP patients often have colorectal adenomatous polyps(26.2%)and reflux esophagitis(21.5%).There are statistically significant differences between the FGP group and the control group in terms of gender,age,history of alcohol consumption,smoking,PPI use,and Hp infection(P＜0.05).Female,41-60 years of age,and history of PPI use(＞12 months)are independent risk factors for FGP,while Hp infection is an independent protective factor for FGP.The positive expression rates of ERα,ERβ,and PR in FGP tissues are significantly higher than those in chronic non-atrophic gastritis tissues,and the expression of ERα,ERβ,and PR in FGP tissues is positively correlated.Conclusions Female,41-60 years of age,and long-term use of PPI(＞12 months)are independent risk factors for FGP,while Hp infection is an independent protective factor for FGP.The expression of ERα,ERβ,and PR is correlated with FGP to some extent.
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