Relationship between serum levels of zonulin and Omentin-1 and the severity and prognosis of ulcerative colitis in patients
Objective This paper intends to explore the relationship between serum levels of zonulin and Omentin-1 and the severity and prognosis of ulcerative colitis(UC)in patients.Methods A total of 93 active UC patients treated at Tangshan Hospital of Traditional Chinese Medicine from September 2020 to December 2022 were selected as the UC group.These patients were divided into the mild group(n=38),the moderate group(n=33),and the severe group(n=22)based on the severity of disease.They were further divided into a good prognosis group(n=61)and a poor prognosis group(n=32)based on prognosis.Additionally,90 healthy individuals who visited the hospital during the same period were selected as the control group.ELISA method was used to detect the levels of serum zonulin and Omentin-1 in each group.ROC curve analysis was performed to assess the predictive value of serum zonulin and Omentin-1 for poor prognosis in UC patients.Multiple logistic regression analysis was conducted to explore factors influencing poor prognosis in UC patients.Results The serum zonulin level in the UC group is significantly higher than that in the control group,while the serum Omentin-1 level is significantly lower(P＜0.05).The serum zonulin level in the severe group are significantly higher than those in the moderate and mild groups,while the serum Omentin-1 level is significantly lower(P＜0.05).The serum levels of zonulin and C-reactive protein(CRP)in the poor prognosis group are significantly higher than those in the good prognosis group,while the serum level of Omentin-1 is significantly lower(P＜0.05).The AUC for serum zonulin and Omentin-1,and their combination in predicting poor prognosis in UC patients are 0.779,0.775,and 0.877,respectively.Serum zonulin is identified as a risk factor for poor prognosis in UC patients,while serum Omentin-1 is a protective factor(P＜0.05).Conclusion Serum levels of zonulin and Omentin-1 are closely related to the severity and prognosis of UC patients.Both biomarkers have potential in evaluating the condition and predicting prognosis in UC patients.
Ulcerative colitisZonulinSerum Omentin-1Severity of diseasePrognosis
万方数据
