Correlation between serum ANGPTL4,THBS2,glucose metabolism,and liver function in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease
Objective This paper aims to explore the relationship between serum angiopoietin-like protein 4(ANGPTL4),thrombospondin-2(THBS2),glucose metabolism,and liver function in patients with type 2 diabetes mellitus(T2DM)and nonalcoholic fatty liver disease(NAFLD).Methods A total of 95 patients with T2DM and NAFLD,admitted to Beijing Electric Power Hospital between April 2021 and April 2023,were selected as the research group,and another 95 patients with simple T2DM,admitted to the hospital during the same period,were selected as the control group.ELISA was used to detect the expression levels of serum ANGPTL4 and THBS2 in both groups.Pearson correlation analysis was performed to explore the relationship between serum ANGPTL4,THBS2,glucose metabolism,and liver function in T2DM patients with NAFLD.Multivariate logistic regression analysis was used to explore the influencing factors of T2DM patients with NAFLD.The ROC curve was used to analyze the diagnostic value of serum ANGPTL4 and THBS2 in T2DM with NAFLD.Results Compared with the control group,the research group has significantly higher levels of HOMA-IR,triglycerides(TG),ALT,ANGPTL4,and THBS2(P＜0.05),while the high-density lipoprotein cholesterol(HDL-C)level is significantly lower(P＜0.05).Pearson correlation analysis reveals that serum ANGPTL4 is positively correlated with HOMA-IR and ALT in T2DM patients with NAFLD(P＜0.05).Similarly,serum THBS2 is positively correlated with HOMA-IR and ALT level(P＜0.05).Multivariate logistic regression analysis shows that ANGPTL4,THBS2,TG,ALT,and HOMA-IR are risk factors for T2DM patients with NAFLD(P＜0.05),while HDL-C is a protective factor for T2DM patients with NAFLD(P＜0.05).The ROC curve analysis shows that the area under the curve(AUC)for the diagnosis of T2DM with NAFLD using serum ANGPTL4 and THBS2 alone and in combination are 0.778,0.807,and 0.897,respectively.The combination of ANGPTL4 and THBS2 provides a higher diagnostic value than that of the detection of serum ANGPTL4 and THBS2 alone(Zcombination-ANGPTL4=4.023,Zcombination-THBS2=3.957,P＜0.001).Conclusions The expression levels of serum ANGPTL4 and THBS2 are both elevated in patients with T2DM and NAFLD.These two biomarkers are closely related to the glucose metabolism and liver function in patients with T2DM combined with NAFLD.
Angiopoietin-like protein 4Thrombospondin-2Type 2 diabetes mellitusNonalcoholic fatty liver diseaseLiver function
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