Correlation between serum levels of TSP-1,IL-1Ra,and organ failure in patients with acute pancreatitis
Objective This paper intends to investigate the correlation between serum levels of thrombospondin-1(TSP-1),interleukin-1 receptor antagonist(IL-1Ra),and organ failure in patients with acute pancreatitis(AP).Methods A total of 165 patients with AP admitted to the No.2 Hospital of Baoding from October 2021 to October 2023,were assigned to the observation group(AP group).Based on the presence of persistent organ failure(POF),patients were divided into the non-POF group(125 cases)and the POF group(40 cases).Additionally,150 healthy individuals who underwent physical examinations at the hospital were assigned to the control group.ELISA was applied to detect serum TSP-1 and IL-1Ra levels.Multivariate logistic regression was used to analyze the factors influencing POF in AP patients.ROC curve analysis was conducted to analyze the predictive value of serum TSP-1 and IL-1Ra for the occurrence of POF in AP patients.Results Compared with the control group,the levels of TSP-1 and IL-1Ra in the AP group are significantly higher(P＜0.05).The APACHEⅡ score and the levels of CRP,IL-6,blood calcium,lipase,TSP-1,and IL-1Ra in the POF group are significantly higher than those in the non-POF group,with statistically significant differences(P＜0.05).Multivariate logistic regression analysis shows that CRP,APACHEⅡ score,TSP-1,and IL-1Ra are independent risk factors for the occurrence of POF in AP patients(P＜0.05).The area under the ROC curve(AUC)for predicting POF based on serum TSP-1 and IL-1Ra alone and in combination are 0.800,0.801,and 0.902,respectively,indicating that the combined detection both biomarkers has higher predictive efficacy than either detection alone(P＜0.05).Conclusions Serum levels of TSP-1 and IL-1Ra in AP patients are elevated and are closely related to the occurrence of POF.Serum TSP-1 and IL-1Ra are expected to be biomarkers for the diagnosis and prediction of POF in AP patients.
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