肿瘤微环境介导乳腺癌靶向治疗耐药的研究进展
Research progress of tumor microenvironment mediated drug resistance in targeted therapy of breast cancer
杨智 1陆以乔 1顾花艳 1丁佳玲 1郭贵龙1
作者信息
- 1. 温州医科大学附属第一医院乳腺外科,温州 325000
- 折叠
摘要
乳腺癌靶向治疗可以显著改善乳腺癌患者的预后、提高生命质量、延长生存期,但是原发性耐药或获得性耐药的出现最终会导致疾病进展、复发或转移.肿瘤微环境(TME)是乳腺癌细胞赖以生存的复杂环境.目前已知乳腺癌细胞和TME是一个功能性整体,它们之间的串扰在乳腺癌进展以及靶向治疗耐药性中起着关键作用.因此明确TME异常对于揭示靶向治疗耐药的潜在机制以及制定针对靶向治疗耐药恶性肿瘤的治疗策略十分重要.
Abstract
Targeted therapy for breast cancer can significantly improve the prognosis,quality of life and survival of breast cancer patients,but the emergence of primary or acquired drug resistance will eventually lead to disease progression,recurrence or metastasis.Tumor microenvironment(TME)is a complex environment for breast cancer cells to survive.Breast cancer cells and TME are currently known to be a functional whole,and the crosstalk between them plays a key role in breast cancer progression and resistance to targeted therapies.Therefore,clarifying TME abnormalities is important to reveal the underlying mechanisms of targeted therapy resistance and to develop therapeutic strategies against targeted therapy-resistant malignancies.
关键词
乳腺肿瘤/肿瘤微环境/分子靶向治疗/抗药性,肿瘤Key words
Breast neoplasms/Tumor microenvironment/Molecular targeted therapy/Drug resistance,neoplasm引用本文复制引用
出版年
2024
NETL
NSTL
万方数据