摘要
Vav鸟嘌呤核苷酸交换因子3(Vav3)蛋白是Rho家族GTP酶的鸟嘌呤核苷酸交换因子之一,由原癌基因Vav3编码,参与调节细胞的增殖、凋亡、分化以及迁移等.近年来,Vav3与多种恶性肿瘤的发展密切相关.在胶质瘤、乳腺癌、非小细胞肺癌、胃癌、胰腺癌、结直肠癌、前列腺癌、卵巢癌、骨肉瘤以及急性白血病中,Vav3的表达不同程度升高,并参与调控多个信号通路,促进肿瘤的进展,影响患者的预后.Vav3有望成为这些恶性肿瘤的潜在治疗靶点.
Abstract
Vav guanine nucleotide exchange factor 3(Vav3)protein is one of the guanine nucleotide exchange factors of the Rho family GTPases.It is encoded by the proto-oncogene Vav3 and is involved in the regulation of cell proliferation and apoptosis,differentiation,migration,etc.In recent years,Vav3 has been closely related to the development of a variety of malignant tumors.In glioma,breast cancer,non-small cell lung cancer,gastric cancer,pancreatic cancer,colorectal cancer,prostate cancer,ovarian cancer,osteosarcoma and acute leukemia,the expression of Vav 3 is elevated to varying degrees,and it participates in regulating multiple signaling pathways,which promotes the progression of tumors and affects the prognosis of patients.Therefore,Vav3 is expected to be a potential therapeutic target for these malignant tumors.
NETL
NSTL
万方数据