Vav guanine nucleotide exchange factor 3(Vav3)protein is one of the guanine nucleotide exchange factors of the Rho family GTPases.It is encoded by the proto-oncogene Vav3 and is involved in the regulation of cell proliferation and apoptosis,differentiation,migration,etc.In recent years,Vav3 has been closely related to the development of a variety of malignant tumors.In glioma,breast cancer,non-small cell lung cancer,gastric cancer,pancreatic cancer,colorectal cancer,prostate cancer,ovarian cancer,osteosarcoma and acute leukemia,the expression of Vav 3 is elevated to varying degrees,and it participates in regulating multiple signaling pathways,which promotes the progression of tumors and affects the prognosis of patients.Therefore,Vav3 is expected to be a potential therapeutic target for these malignant tumors.
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