Protein S-palmitoylation is a reversible post-translational modification of lipids that regulates protein localization,stability and protein-protein interactions.The thioesterification of palmitate to internal cysteine residues is catalyzed by palmitoyltransferase,while the removal of palmitate is mainly catalyzed by acyl-protein thioesterase.The S-palmitoylation of some tumor-related proteins is abnormally altered in tumor,which is closely related to the biological processes such as tumor cell proliferation,invasion,metastasis,drug resistance and immune response.Furtherly,exploring the characteristics of protein S-palmitoy-lation and its role in tumor progression could deliver new ideas in targeting protein S-palmitoylation for tumor therapy.
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