Circular RNA(circRNA)has shown great application potential in triple-negative breast cancer(TNBC).The aberrantly expressed circRNAs participate in the occurrence and development of TNBC by acting as microRNA sponges,regulating gene expression,interacting with functional proteins,and encoding short peptides or proteins to regulate the biological processes of TNBC cell proliferation,apoptosis,invasion,metastasis,and drug resistance.circRNAs are emerging biomarkers for early diagnosis and prognosis of TNBC,as well as new therapeutic targets with potential clinical value.Further elucidation of the complex mechanism of circRNAs in TNBC may provide an important theoretical basis for the development of precise therapeutic strategies for TNBC.
关键词
三阴性乳腺癌/RNA,环状/致癌作用/生物疗法
Key words
Triple negative breast neoplasms/RNA,circular/Carcinogenesis/Biological therapy
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