首页|C-反应蛋白与非小细胞肺癌免疫治疗预后的研究进展

C-反应蛋白与非小细胞肺癌免疫治疗预后的研究进展

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免疫治疗已成为驱动基因阴性晚期非小细胞肺癌(NSCLC)的一线标准治疗方案,但并非所有的患者均能从免疫治疗中获益,甚至可发生严重的不良反应,确定免疫治疗临床反应预测因子至关重要.多项研究表明,基线C-反应蛋白(CRP)升高或治疗过程中CRP持续升高可能提示患者预后不良,并且高CRP可能与不良反应有一定的相关性,CRP在NSCLC免疫治疗过程中的动态变化可能成为患者预后的一个重要预测因素.
Research progress in C-reactive protein and the prognosis of immunotherapy for non-small cell lung cancer
Immunotherapy has become the first-line standard treatment option for driver gene-negative advanced non-small cell lung cancer(NSCLC).But not all patients can benefit from immunotherapy,and can even have serious adverse reactions.It is crucial to identify the predictors of clinical response to immunotherapy.Several studies have shown that elevated baseline C-reactive protein(CRP)or persistent elevation of CRP during the treatment process may indicate a poorer prognosis for patients,and high CRP may be correlated with adverse reactions.Attention to the dynamic changes of CRP during immunotherapy for NSCLC may become an important predictor of prognosis.

Carcinoma,non-small cell lungC-reactive proteinImmunotherapyPrognosis

伏彩红、辛元春、顾峰、吴玉强、李慧慧、马琴、刘喜婷、杨磊

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甘肃省肿瘤医院呼吸肿瘤内科,兰州 730000

甘肃省肿瘤医院放疗科,兰州 730000

癌,非小细胞肺 C反应蛋白质 免疫疗法 预后

2024

国际肿瘤学杂志
中华医学会,山东省医学科学院

国际肿瘤学杂志

CSTPCD
影响因子:0.317
ISSN:1673-422X
年,卷(期):2024.51(12)