Role of exosomes in bone metastasis of prostate cancer
Bone is the main metastatic site of prostate cancer,and bone metastasis of prostate cancer seriously affects the prognosis and quality of life of patients.Exosomes are lipid bilayer vesicles secreted by cells,which play a significant role in intercellular communication.Exosomes can regulate the specific colonization of prostate cancer cells in bone tissue,reshape the pre-metastatic niche conducive to the survival of tumor cells,and modulate the immune microenvironment of bone.At the same time,exosomes can also regulate the differentiation and maturation of osteoblasts and osteoclasts,resulting in bone remodeling.Further understanding of the role of exosomes in bone metastasis of prostate cancer will help to develop new targets for delaying the progression of bone metastasis.
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