活力苏口服液联合舍曲林治疗气血亏虚型产后抑郁症
Huolisuoral liquid combined with sertraline in the treatment of patients with postpartum depression due to Qi-Blood deficiency
刘桂玲1
作者信息
- 1. 071000 河北省保定市第三医院妇产科
- 折叠
摘要
目的：观察活力苏口服液联合舍曲林对气血亏虚型产后抑郁症患者血清去甲肾上腺素（NE）、五羟色胺（5-HT）的影响，探讨其对产后抑郁症的临床疗效。方法82例产后抑郁症患者按照随机数字表法分为治疗组43例、对照组39例。对照组口服舍曲林，治疗组在对照组治疗基础上加服活力苏口服液，共8周。采用汉密尔顿抑郁量表（hamilton depression scale, HAMD）评价抑郁程度，并检测血清NE、5-HT水平。结果治疗后8周时，治疗组和对照组HAMD评分均显著低于治疗前[治疗组：（4.73±3.57）分比（21.49±3.20）分；对照组：（9.11±3.13）分比（21.11±3.12）分；P均＜0.05]，血清NE[治疗组：（137.89±56.81）pg/ml比（96.19±36.48）pg/ml；对照组：（127.71±54.27）pg/ml比（96.15±34.33）pg/ml]、5-HT[治疗组：（153.43±24.89）ng/ml比（45.03±9.09）ng/ml；对照组：（125.31±25.09）ng/ml比（44.46±8.17）ng/ml]均显著高于治疗前（P均＜0.05）。2组治疗后比较， HAMD评分以及血清NE和5-HT水平差异均有统计学意义（P均＜0.05）。结论活力苏口服液联合舍曲林可降低气血亏虚型抑郁症患者HAMD评分，升高血清NE和5-HT水平，改善气血亏虚型产后抑郁症患者的抑郁症状。
Abstract
Objective To observe the effects ofHuolisu oral liquid combined with sertraline on the serum levels of norepinephrine (NE) and 5-hydroxytryptamine (5-HT) in patients with postpartum depression due to Qi-Blood deficiency, and to explore therapeutic efficiency.Methods A total of 82 patients with postpartum depression due to Qi-Blood deficiency were randomly divided into a treatment group with 43 patients and a control group with 39 patients. The patients in the treatment group were treated withHuolisu oral liquid and sertraline, and those in the control group were treated with sertraline alone for 8 weeks. Severity of depression was evaluated with the Hamilton Depression Scale (HAMD), and the serum levels of NE and 5-HT was detected.Results The HAMD scores after the treatment for 8 weeks were significantly lower than before the treatment in both groups (4.73 ± 3.57vs. 21.49 ± 3.20 in the treatment group, 9.11 ± 3.13vs. 21.11 ± 3.12 in the control group; allP<0.05). The serum levels of NE (137.89 ± 56.81 pg/mlvs. 96.19 ± 36.48 pg/ml in the treatment group, 127.71 ± 54.27 pg/mlvs.96.15 ± 34.33 pg/ml in the control group; allP<0.05) and 5-HT (153.43 ± 24.89 ng/mlvs. 45.03 ± 9.09 ng/ml in the treatment group, 125.31 ± 25.09 ng/mlvs. 44.46 ± 8.17 ng/ml in the control group; allP<0.05) after the treatment for 8 weeks were significantly higher than before the treatment in both groups. After the treatment for 8 weeks, the HAMD score was significantly lower, the serum levels of NE and 5-HT were significantly higher in the treatment group than those in the control group (allP<0.05). ConclusionsHuolisu oral liquid combined with sertraline can significantly decrease HAMD score, and increase serum levels of NE and 5-HT, obviously improve the depression symptoms in patients with postpartum depression due to Qi-Blood Deficiency.
关键词
抑郁症,产后/气血两虚/活力苏口服液/盐酸舍曲林/去甲肾上腺素/血清素Key words
Depression, postpartum/Qi-Blood Deficiency/Sertraline/Norepinephrine/Serotonin/Huolisu oral liquid引用本文复制引用
出版年
2015
NETL
NSTL
维普
万方数据