The signaling pathways involved in acupuncture intervention in post-stroke depression(PSD)mainly include cAMP signaling pathway,MAPK signaling pathway,PI3K/Akt/mTOR signaling pathway,NF-κB signaling pathway,CREB signaling pathway,and CaMK signaling pathway.A variety of regulatory networks are formed between these signaling pathways,which play a key role in reducing inflammation,inhibiting apoptosis,improving neuroplasticity,promoting angiogenesis,and protecting neurons.
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