摘要
针刺干预卒中后抑郁(PSD)主要涉及cAMP信号通路、MAPK信号通路、PI3K/Akt/mTOR信号通路、NF-κB信号通路、CREB信号通路,CaMK信号通路.这些信号通路之间形成了多样的调控网络,起到减轻炎症反应,抑制细胞凋亡,提高神经可塑性,促进血管新生,保护神经元等关键作用.
Abstract
The signaling pathways involved in acupuncture intervention in post-stroke depression(PSD)mainly include cAMP signaling pathway,MAPK signaling pathway,PI3K/Akt/mTOR signaling pathway,NF-κB signaling pathway,CREB signaling pathway,and CaMK signaling pathway.A variety of regulatory networks are formed between these signaling pathways,which play a key role in reducing inflammation,inhibiting apoptosis,improving neuroplasticity,promoting angiogenesis,and protecting neurons.
基金项目
陕西省自然科学基础研究计划项目(2021JM-578)
维普
万方数据