雷公藤广泛应用于自身免疫系统疾病的治疗，但其明显的生殖毒性使其临床应用及推广受到限制。目前针对雷公藤的生殖损伤，尚未有明确的解决方案。中医认为，雷公藤的生殖毒性当责之于其辛苦寒凉之性，久用可燥肝血、伤肝阳、耗肾精、损肾阳，破坏脏腑的气血阴阳平衡，致不孕不育。本文根据肝肾与人体生殖功能的联系，提出从“乙癸同源”角度认识雷公藤的生殖毒性，并依据“肝肾同治”思想探索雷公藤生殖毒性的减毒之法，以期为临床安全应用拓展中医理论思考。 Tripterygium wilfordii is widely used in the treatment of autoimmune system diseases, but its obvious reproductive toxicity limits the clinical application and promotion of the drug. At present, there is no clear solution to the reproductive injury of Tripterygium wilfordii. TCM believes that its reproductive toxicity lies in its properties of pungent, bitter, and cold. Long-term use can dry liver and blood, hurt liver and yang, consume kidney essence, damage kidney and yang, destroy the balance of qi and blood, yin and yang in the internal organs, and cause infertility. Based on the relationship between liver and kidney and human reproductive function, this article proposed to understand the reproductive toxicity of Tripterygium wilfordii from the perspective of "Yi and Gui homology", and explored the method of reducing the reproductive toxicity of Tripterygium wilfordii according to the thought of "treating liver and kidney together", in order to expand the theoretical thinking of TCM for the safe clinical application of this drug.
Exploration on the idea of reducing the reproductive toxicity of Tripterygium wilfordii from the theory of "Yi and Gui homology" in TCM
Tripterygium wilfordii is widely used in the treatment of autoimmune system diseases, but its obvious reproductive toxicity limits the clinical application and promotion of the drug. At present, there is no clear solution to the reproductive injury of Tripterygium wilfordii. TCM believes that its reproductive toxicity lies in its properties of pungent, bitter, and cold. Long-term use can dry liver and blood, hurt liver and yang, consume kidney essence, damage kidney and yang, destroy the balance of qi and blood, yin and yang in the internal organs, and cause infertility. Based on the relationship between liver and kidney and human reproductive function, this article proposed to understand the reproductive toxicity of Tripterygium wilfordii from the perspective of "Yi and Gui homology", and explored the method of reducing the reproductive toxicity of Tripterygium wilfordii according to the thought of "treating liver and kidney together", in order to expand the theoretical thinking of TCM for the safe clinical application of this drug.
Tripterygium wilfordiiYi and Gui homologyHomogeny of liver and kidneyReproductive toxicity
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