目的 评价逍生散超声雾化联合睑板腺按摩治疗睑板腺功能障碍型干眼肝郁阴虚证的临床疗效。 方法 随机对照试验研究。选取2021年3－9月中国中医科学院眼科医院睑板腺功能障碍型干眼肝郁阴虚证患者50例（100只眼）作为观察对象，按随机数字表法分为2组，每组25例（50只眼）。对照组予0.1%玻璃酸钠滴眼液联合睑板腺按摩，治疗组予逍生散超声雾化联合睑板腺按摩。2组均治疗4周。分别于治疗前后观察患者泪膜破裂时间（BUT），行泪液分泌试验（SⅠT）并进行角结膜荧光染色（FL）评分、中医症状评分、睑板腺功能评分，评价临床疗效。 结果 治疗组治疗后BUT较对照组延长（t=8.76，P<0.01）、SⅠT较对照组升高（t=6.18，P<0.01），FL评分、中医症状积分、睑板腺功能评分较对照组降低（t值分别为2.19、5.36、12.09，P<0.01）。治疗组总有效率为96.0%（24/25）、对照组为68.0%（17/25），2组比较差异有统计学意义（χ2=4.88，P=0.027）。 结论 逍生散超声雾化联合睑板腺按摩可有效改善睑板腺功能障碍型干眼肝郁阴虚证患者的临床症状，且安全有效。 Objective To observe the clinical efficacy of Xiaosheng Powder ultrasonic nebulization combined with meibomian gland massage in treating liver depression and Yin deficiency pattern of meibomian gland dysfunction dry eye. Methods Randomized controlled trial. From March 2021 to September 2021, a total of 50 patients (100 eyes) diagnosed with meibomian gland dysfunction dry eye of the liver depression and Yin deficiency pattern at the Ophthalmology Hospital of China Academy of Chinese Medical Sciences were selected. They were randomly divided into two groups using a random number table, with 25 patients (50 eyes) in each group. The control group received 0.1% sodium hyaluronate eye drops combined with meibomian gland massage, while the treatment group received Xiaosheng Powder nebulization combined with meibomian gland massage. Both groups were treated for 4 weeks. Before and after treatment, the tear film break-up time (BUT), Schirmer I test (SIT), corneal fluorescein staining (FL) scores, TCM symptom scores, and meibomian gland function scores were observed and evaluated. Adverse reactions were recorded. Results After treatment, the treatment group exhibited statistically significant improvements compared to the control group in the following aspects: BUT was significantly longer in the treatment group (t=8.76, P<0.01) SIT values were significantly higher in the treatment group (t=6.18, P<0.01) FL scores, TCM symptom scores and meibomian gland function scores were significantly lower than in the treatment group (t values were 2.19, 5.36 and 12.09, P<0.01). The total effective rate in the treatment group was 96.0% (24/25), while in the control group, it was 68.0% (17/25), and the difference between the two groups was statistically significant (χ2=4.88, P=0.027). Conclusion The combination of Xiaosheng Powder ultrasonic nebulization and meibomian gland massage is effective in improving the clinical symptoms of patients with meibomian gland dysfunction dry eye of the liver depression and Yin deficiency pattern. Furthermore, this approach is considered safe and efficient.
Clinical study on Xiaosheng Powder ultrasonic nebulization combined with meibomian gland massage for the patients with meibomian gland dysfunction dry eye and pattern of liver depression and Yin deficiency
Objective To observe the clinical efficacy of Xiaosheng Powder ultrasonic nebulization combined with meibomian gland massage in treating liver depression and Yin deficiency pattern of meibomian gland dysfunction dry eye. Methods Randomized controlled trial. From March 2021 to September 2021, a total of 50 patients (100 eyes) diagnosed with meibomian gland dysfunction dry eye of the liver depression and Yin deficiency pattern at the Ophthalmology Hospital of China Academy of Chinese Medical Sciences were selected. They were randomly divided into two groups using a random number table, with 25 patients (50 eyes) in each group. The control group received 0.1% sodium hyaluronate eye drops combined with meibomian gland massage, while the treatment group received Xiaosheng Powder nebulization combined with meibomian gland massage. Both groups were treated for 4 weeks. Before and after treatment, the tear film break-up time (BUT), Schirmer I test (SIT), corneal fluorescein staining (FL) scores, TCM symptom scores, and meibomian gland function scores were observed and evaluated. Adverse reactions were recorded. Results After treatment, the treatment group exhibited statistically significant improvements compared to the control group in the following aspects: BUT was significantly longer in the treatment group (t=8.76, P<0.01) SIT values were significantly higher in the treatment group (t=6.18, P<0.01) FL scores, TCM symptom scores and meibomian gland function scores were significantly lower than in the treatment group (t values were 2.19, 5.36 and 12.09, P<0.01). The total effective rate in the treatment group was 96.0% (24/25), while in the control group, it was 68.0% (17/25), and the difference between the two groups was statistically significant (χ2=4.88, P=0.027). Conclusion The combination of Xiaosheng Powder ultrasonic nebulization and meibomian gland massage is effective in improving the clinical symptoms of patients with meibomian gland dysfunction dry eye of the liver depression and Yin deficiency pattern. Furthermore, this approach is considered safe and efficient.
XerophthalmiaMeibomian gland dysfunctionXiaosheng PowderAtomizationMeibomian gland massageSyndrome of liver depression and Yin deficiency
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