Research progress in clinical application and mechanism of Sijunzi Decoction in the treatment of gastric cancer
赵景涛 1宁博 1肖萌 2秦悦 1李亚楠 1杨秋燕 1肖海娟 3常久
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作者信息
1. 陕西中医药大学2021级硕士研究生，咸阳 712046
2. 陕西中医药大学2022级硕士研究生，咸阳 712046
3. 陕西中医药大学附属医院肿瘤三科，咸阳 712000
折叠
摘要
四君子汤为健脾益气之经典名方，临床治疗胃癌可取得一定效果，可改善化疗耐药，减轻化疗毒副作用，促进术后恢复，增强患者免疫力，改善患者营养状况，提高患者生活质量及防治癌前病变等。网络药理学研究表明，四君子汤通过多活性成分、多作用靶点、多途径发挥抗胃癌作用，且槲皮素可能为四君子汤中发挥抗胃癌作用的主要活性成分。四君子汤治疗胃癌的主要机制包括调控细胞周期及凋亡相关基因蛋白表达，以及抑制胃癌细胞增殖、迁移、侵袭及胃癌干细胞特性。 As a classic prescription for invigorating spleen and replenishing qi, Sijunzi Decoction has a good clinical efficacy in the treatment of gastric cancer. It can improve chemotherapy resistance, reduce the toxic and side effects of chemotherapy, promote postoperative recovery, enhance immunity, improve the nutritional status of patients, improve the quality of life of patients and prevent precancerous lesions. Network pharmacology studies have shown that Sijunzi Decoction exerts anti-gastric cancer effects through multiple active ingredients, multiple targets and multiple pathways, and quercetin may be the main active component in Sijunzi Decoction to exert anti-gastric cancer effects. The main mechanisms of Sijunzi Decoction in the treatment of gastric cancer include regulating the expression of cell cycle and apoptosis-related gene proteins, and inhibiting the proliferation, migration, invasion and gastric cancer stem cell characteristics of gastric cancer cells.
Abstract
As a classic prescription for invigorating spleen and replenishing qi, Sijunzi Decoction has a good clinical efficacy in the treatment of gastric cancer. It can improve chemotherapy resistance, reduce the toxic and side effects of chemotherapy, promote postoperative recovery, enhance immunity, improve the nutritional status of patients, improve the quality of life of patients and prevent precancerous lesions. Network pharmacology studies have shown that Sijunzi Decoction exerts anti-gastric cancer effects through multiple active ingredients, multiple targets and multiple pathways, and quercetin may be the main active component in Sijunzi Decoction to exert anti-gastric cancer effects. The main mechanisms of Sijunzi Decoction in the treatment of gastric cancer include regulating the expression of cell cycle and apoptosis-related gene proteins, and inhibiting the proliferation, migration, invasion and gastric cancer stem cell characteristics of gastric cancer cells.
关键词
四君子汤/胃癌/临床应用/机制研究/研究进展/综述
Key words
Si Jun Zi Tang/Gastric cancer/Clinical application/Mechanism study/Research progress/Review
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